1. |
Introduction |
1.1. |
Scope |
1.2. |
Terms of Reference |
1.3. |
Methodology |
1.4. |
Who is This Report For? |
2. |
Executive Summary |
2.1. |
Main Findings |
2.2. |
Main Conclusions |
2.3. |
Global Bio-Detection Market Forecast – 2010-2014 |
2.3.1. |
Global Systems, Service & Upgrade Markets – 2010-2014 |
2.3.2. |
Markets by Countries & Regions – 2010-2014 |
2.3.3. |
Markets by Outdoor, Indoor, Hand-Held and Mobile Lab – 2010-2014 |
2.3.4. |
Systems Market by Technology Generation – 2010-2014 |
2.3.5. |
Service & Upgrade Market by Generation – 2010-2014 |
2.4. |
Business Opportunities |
2.4.1. |
Bio-Surveillance, Detection & Bio-forensics Business Challenges – 2010-2014 |
2.5. |
Technology Outlook |
3. |
Bio-Terror |
4. |
Forty Countries: Bio-Security Status Review |
4.1. |
Background |
4.1.1. |
Forty Countries Bio-Technology & Bio-Defense Performance Score |
5. |
Market Drivers |
6. |
Market Inhibitors |
7. |
Bio-Detection Industry Competitive Analysis |
8. |
Industry SWOT Analysis |
8.1. |
Scope |
8.2. |
SWOT Analysis |
9. |
The Bio-Detection Process |
9.1. |
Sampling the Environment |
9.2. |
Bio-Detectors in a Multitude of Ambient Settings |
9.3. |
Bio-Detection Triggering |
9.4. |
Sample Collection |
9.5. |
Bio-Particle Detectors |
9.6. |
Bio-Agent Identification |
10. |
Bio-Detection Technological Challenges |
10.1. |
Challenge 1 – Detection of Small Particle Concentration |
10.2. |
Challenge 2 – Bio-Background Suppression |
10.3. |
Challenge 3 – Expensive Reagents |
10.4. |
Challenge 4 – Expensive Equipment Maintenance |
10.5. |
Challenge 5 – Adapting Equipment to Changing Environments |
10.6. |
Challenge 6 – Dealing With Emerging Threats |
11. |
Present and Pipeline Bio-Detection Technologies |
11.1. |
Bio-Detection – Core Technologies Comparison |
11.2. |
Collector/Concentrator Core Technologies |
11.3. |
Cyclone Collectors |
11.4. |
Variable Particle-Size Impactor |
11.5. |
Virtual Impactors |
11.6. |
Impingers |
11.7. |
Reagent-less Trigger Core Technologies |
11.7.1. |
Flow Cytometry |
11.7.2. |
Particle Sizing |
11.7.3. |
Gas Chromatography |
11.7.4. |
Trigger Technologies – Drivers |
11.7.5. |
Trigger Technologies – Inhibitors |
11.8. |
DNA Based Diagnostic Core Technologies |
11.8.1. |
Overview of DNA-Based Detection |
11.8.2. |
Polymerase Chain Reaction (PCR) |
11.8.3. |
DNA / RNA Microarrays |
11.8.4. |
DNA Technology Drivers |
11.8.5. |
DNA Technology Inhibitors |
11.9. |
Antibody-Antigen Diagnostic Core Technologies |
11.9.1. |
Overview of Antibody-Antigen Reaction |
11.9.2. |
Hand-Held Immuno-Chromatographic Assays (HHA) |
11.9.3. |
Magnetic Microbead-Base Assays |
11.9.4. |
Microfluidic Devices – “Lab on a Chip” |
11.9.5. |
Fluorescence Imaging |
11.9.6. |
Electrochemical-Luminescence (ECL) |
11.9.7. |
Antibody/Antigen Technology – Drivers |
11.9.8. |
Antibody/Antigen Technology – Inhibitors |
11.1. |
Signal Analysis Algorithms |
11.10.1. |
Clustering / Classifier Algorithms |
11.10.2. |
Image Analysis Algorithms |
11.10.3. |
Decision Algorithms |
11.10.4. |
Drivers |
11.10.5. |
Inhibitors |
11.11. |
Rapid Microbiological Technologies |
12. |
Bio- Detection – Analysis by Application |
12.1.1. |
Application 1 – Emergency Responder Hand-Held Detectors |
12.1.2. |
Application 2 – Emergency Responder Mobile Labs |
12.1.3. |
Application 3 – Indoor Standoff Detectors |
12.1.4. |
Application 4 – Outdoor Standoff Detectors |
13. |
Global Bio- Detection Market – 2010-2014 |
13.1. |
The Global Market Overview |
13.2. |
Markets by Systems, Upgrade and Service Segments – 2010-2014 |
13.3. |
Global Market by Countries & Regions – 2010-2014 |
13.4. |
Global Systems Market by Technological Generation – 2010-2014 |
13.5. |
Global Systems Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments – 2010-2014 |
13.6. |
Global Service & Upgrade Market by Technological Generation – 2010-2014 |
13.6.1. |
Global Service and Upgrade Business by Technological Generation – 2010-2014 |
13.6.2. |
Global Service & Upgrade Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments – 2010-2014 |
14. |
US Bio-Detection Market – 2010-2014 |
14.1. |
Leading Bio-Security Projects |
14.1.1. |
Project BioWatch |
14.1.2. |
Project BioSense |
14.1.3. |
Project BioShield |
14.2. |
US Bio-Defense Background & Analysis |
14.3. |
US Bio-Defense Funding |
14.3.1. |
DHHS Bio-Defense Missions and Funding |
14.3.2. |
DHS Bio-Defense Missions and Funding |
14.3.3. |
DOD Bio-Defense Missions and Funding |
14.3.4. |
DOA Bio-Defense Missions and Funding |
14.3.5. |
EPA Bio-Defense Missions and Funding |
14.3.6. |
Other Bio-Defense Missions and Funding |
14.4. |
The Obama Administration Bio-Defense Strategy |
14.5. |
Market Drivers |
14.6. |
Market Inhibitors |
14.7. |
US Bio-Detection Systems Market – 2010-2014 |
14.7.1. |
Sales by Generation Forecast |
14.7.2. |
US Bio-Detection Systems Market by Modality Forecast |
14.8. |
US Outdoor Standoff Bio-Detection Systems Market – 2010-2014 |
14.8.1. |
Sales Outlook |
14.9. |
US Indoor Bio-Detection Systems Market – 2010-2014 |
14.9.1. |
Indoor Market Outlook |
14.1. |
US Hand-Held Detection Systems Market – 2010-2014 |
14.10.1. |
Hand-Held Detection Systems Market Outlook |
14.11. |
US Mobile Bio-Detection Labs Market – 2010-2014 |
14.11.1. |
Market Outlook |
14.12. |
US Service Business – 2010-2014 |
14.12.1. |
Service & Upgrade Business by Modality – 2010-2014 |
14.12.2. |
Service Business by Generation – 2010-2014 |
15. |
The UK, Germany, France, Italy and Spain HLS-HLD Bio-Detection Market |
15.1. |
The European Union |
15.1.1. |
The European Union Bio-Defense Background |
15.1.2. |
EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks (BICHAT) |
15.1.3. |
EU Bio-Defense Research Programs |
15.2. |
The UK |
15.2.1. |
Bio-Defense Strategy |
15.2.2. |
Main Bio-Defense Initiatives |
15.3. |
Germany |
15.3.1. |
Bio-Defense Strategy |
15.3.2. |
Main Bio-Defense Initiatives |
15.3.3. |
Bio- Detection R&D Projects |
15.4. |
France |
15.5. |
Italy |
15.6. |
Spain |
15.7. |
Market Drivers |
15.8. |
Market Inhibitors |
15.9. |
UK, Germany, France, Italy and Spain Bio-Detection Systems Market – 2010-2014 |
15.9.1. |
Sales by Technology Generations Forecast |
15.9.2. |
Sales by Modality Forecast |
15.1. |
UK, Germany, France, Italy and Spain Outdoor Standoff Bio-Detection Systems Market Forecast – 2010-2014 |
15.10.1. |
Systems Market Outlook |
15.11. |
UK, Germany, France, Italy and Spain Indoor Bio-Detection Systems Market – 2010-2014 |
15.11.1. |
Systems Market Outlook |
15.12. |
UK, Germany, France, Italy and Spain Hand-Held Detection Systems Market – 2010-2014 |
15.12.1. |
Systems Market Outlook |
15.13. |
UK, Germany, France, Italy and Spain Mobile Bio-Detection Labs Market – 2010-2014 |
15.13.1. |
Market Outlook |
15.14. |
UK, Germany, France, Italy and Spain Service Business – 2010-2014 |
15.14.1. |
Service & Upgrade Business by Modality – 2010-2014 |
15.14.2. |
Service Business by Generation – 2010-2014 |
16. |
China, Taiwan, Japan, India and Middle East HLS-HLD Bio-Detection Market |
16.1. |
Asian Countries Bio- Defense Background |
16.2. |
Japan |
16.3. |
China |
16.4. |
Taiwan |
16.5. |
India |
16.6. |
Singapore |
16.7. |
Middle East |
16.8. |
Market Drivers |
16.9. |
Market Inhibitors |
16.1. |
China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market – 2010-2014 |
16.10.1. |
Sales by Technology Generation – 2010-2014 |
16.10.2. |
Market by Modality – 2010-2014 |
16.11. |
China, Taiwan, Japan, India and Middle East Bio-Detection Outdoor Systems Market – 2010-2014 |
16.11.1. |
Sales Outlook |
16.12. |
China, Taiwan, Japan, India and Middle East Bio-Detection Indoor Systems Market – 2010-2014 |
16.12.1. |
Market Outlook |
16.13. |
China, Taiwan, Japan, India and Middle East Hand-Held Detection Systems Market – 2010-2014 |
16.13.1. |
Market Outlook |
16.14. |
China, Taiwan, Japan, India and Middle East Bio-Detection Mobile Labs Market – 2010-2014 |
16.14.1. |
Market Outlook |
16.15. |
China, Taiwan, Japan, India and Middle East Service Business – 2010-2014 |
16.15.1. |
Service & Upgrade Business by Modality – 2010-2014 |
16.15.2. |
Service Business by Generation – 2008-2014 |
17. |
The Rest of the World HLS-HLD Bio-Detection Market |
17.1. |
ROW: Bio-Defense Background |
17.1.1. |
Russia and CIS |
17.1.2. |
Russian Government Bio-Security Initiatives |
17.1.3. |
International Science and Technology Center (ISTC) |
17.1.4. |
Canada |
17.1.5. |
Australia |
17.2. |
Market Drivers |
17.3. |
Market Inhibitors |
17.4. |
ROW Bio-Detection Systems Market – 2010-2014 |
17.4.1. |
Sales Forecast by Generation |
17.4.2. |
Market by Modality Forecast |
17.5. |
ROW Outdoor Bio-Detection Systems Market – 2010-2014 |
17.5.1. |
Sales Outlook |
17.6. |
ROW Indoor Bio-Detection Systems Market – 2010-2014 |
17.6.1. |
Market Outlook |
17.7. |
ROW Hand-Held Detection Systems Market – 2010-2014 |
17.7.1. |
ROW Market Outlook |
17.8. |
ROW Mobile Bio-Detection Labs Market – 2010-2014 |
17.8.1. |
Market Outlook |
17.9. |
ROW Service Business – 2010-2014 |
17.9.1. |
ROW Service & Upgrade Business by Modality |
17.9.2. |
Service Business by Generation – 2010-2014 |
18. |
Bio-Detection Business Opportunities – 2010-2014 |
18.1. |
Historical Perspective: A Market Waiting for Transition |
18.1.1. |
The Current and Future HLS Bio-Defense Strategy for Detection |
18.1.2. |
Factors Affecting Biological Detectors Deployment and Technologies – 2010-2014 |
18.1.3. |
Biological Detection Technology Timeline – 1992-2014 |
18.2. |
Business Opportunities for Next Generation HLS Bio-Detection Systems |
18.2.1. |
Business Opportunity 1 – Emerging Threats |
18.2.2. |
Business Opportunity 2 – Human Sentinel Surveillance System |
18.2.3. |
Business Opportunity 3 – Animal Sentinel Surveillance System |
18.2.4. |
Business Opportunity 4 – Biological IC3 – Biological Threat Assessment Intelligence Command, Control, and Communication Infrastructure |
18.2.5. |
Business Opportunity 5 – Reducing False Alarms – Less False Positives and False Negatives |
18.2.6. |
Business Opportunity 6 – Reducing Cost – Minimizing Use of Non-Reusable Reagents |
18.3. |
Outdoor Standoff Biological Detectors |
18.3.1. |
Business Opportunity 7 – Bio-agent Autonomous Networked Detectors (BAND) |
18.3.2. |
Business Opportunity 8 – Rapid Automated Biological Identification System (RABIS) |
18.3.3. |
Business Opportunity 9 – First Responder Portable Hand-Held Detector |
18.3.4. |
Business Opportunity 10 – First-Responder Mobile Biological Detection Station |
18.3.5. |
Business Opportunity 11 – Regional Automatic Detector – Outdoor Standoff Detectors |
18.3.6. |
Business Opportunity 12 – Networked Automatic Detector – Indoor Standoff Detectors |
18.3.7. |
Business Opportunity 13 – External Dissemination of Bio-Agent Detection |
18.3.8. |
Business Opportunity 14 – Internal Dissemination of Bio-Agent |
18.4. |
Other Bio-Detection Technologies – Business Opportunities |
18.4.1. |
Business Opportunity 15 – “Lab on a Chip” – Miniature Detection Devices |
18.4.2. |
Business Opportunity 16 – Reagent-less Specific Detection Assays |
18.4.3. |
Business Opportunity 17 – Laser-Induced Breakdown Spectroscopy (LIBS) |
18.4.4. |
Business Opportunity 18 – Raman Spectroscopy-based Reagent-less Detection |
18.5. |
Future Technologies and Systems |
19. |
Bio-Defense U.S. Federal R&D Funding – 2010-2014 |
19.1. |
Summary & Outlook |
19.2. |
Bio-Defense Federal R&D Funding Forecast – 2010-2014 |
19.2.1. |
Department of Homeland Security Bio-Security R&D |
19.2.2. |
Department of Defense Bio-Security R&D |
19.2.3. |
Department of Health and Human Services Bio-Security R&D |
19.2.4. |
Other Agencies Bio-Security R&D |
19.3. |
HLS-HLD Bio-Detection R&D Funding – Drivers |
19.4. |
HLS-HLD Bio-Detection R&D Funding – Inhibitors |
19.5. |
Department of Homeland Security – Biological Detection HLS Technologies R&D Programs |
19.5.1. |
Surveillance and Detection R&D |
19.5.2. |
Rapid Development for Sensors for Novel Threat Agents |
19.5.3. |
Cross Correlation of Environmental Biological Sensors and Human Illness |
19.5.4. |
Facility Airborne Biological Toxin Alarm System (FABTAS) |
19.5.5. |
Field-Deployable Detection Technology for the Identification of Biological Toxins |
19.5.6. |
Forensics |
19.6. |
Defense Advanced Research Project Agency (DARPA) – Biological Detection HLS Technologies R&D Programs |
19.6.1. |
Hand-held Isothermal Silver Standard Sensor (HISSS) |
19.6.2. |
Triangulation Identification for Genetic Evaluation of Biological Risk (TIGER) |
19.6.3. |
Spectral Sensing of Bio-Aerosols (SSBA) |
19.6.4. |
Threat Agent Cloud Tactical Intercept Countermeasure (TACTIC) |
19.6.5. |
Immune Buildings |
19.7. |
Chemical Biological Defense Program (CBDP) – Biological Detection HLS Technologies R&D Programs |
19.7.1. |
Project CB1 – Biological Defense (Basic Research) – Detection |
19.7.2. |
Project CB2 – Biological Defense (Applied Research) – Detection |
19.7.3. |
Project CB3 – Biological Defense (ATD) – Detection |
19.7.4. |
Project CA5 Contamination Avoidance (SDD) |
19.8. |
Technical Support Working Group (TSWG) – Biological Detection HLS Technologies R&D Programs |
19.8.1. |
Real-Time Biological Aerosol Detection |
20. |
Vendors |
20.1. |
20/20 GeneSystems Inc. |
20.2. |
Advnt Biotechnologies |
20.3. |
Agilent Technologies |
20.4. |
Alexeter Technologies |
20.5. |
ANP Technologies, Inc. |
20.6. |
BAS – Biological Alarm Systems Ltd. (Israel) |
20.7. |
BD Biosciences Immunocytometry Systems |
20.8. |
Bertin Technologies |
20.9. |
BioDefense Corporation |
20.1. |
BioDETECT AS |
20.11. |
BioSentinel Pharmaceuticals LLC |
20.12. |
3M Microbiology (Biotrace International, Ltd.) |
20.13. |
BioTraces, Inc. |
20.14. |
BioVeris Corporation |
20.15. |
Biral |
20.16. |
Cepheid |
20.17. |
Commonwealth Biotechnologies, Inc. |
20.18. |
Dycor Technologies Ltd. |
20.19. |
Environics Oy |
20.2. |
Evogen, Inc. |
20.21. |
General Dynamics Canada |
20.22. |
GenPrime, Inc. |
20.23. |
Groton Biosystems |
20.24. |
Haztech Systems, Inc. |
20.25. |
Idaho Technology, Inc. |
20.26. |
JMAR Technologies, Inc. |
20.27. |
New Horizons Diagnostics |
20.28. |
Proengin |
20.29. |
QTL Biodetection |
20.3. |
Research International |
20.31. |
Response Biomedical |
20.32. |
Roche Applied Science |
20.33. |
Smiths Detection |
20.34. |
Tetracore, Inc. |
21. |
Prices of Bio-Detection Equipment |
22. |
Pricing Outlook – 2010-2014 |
23. |
Bio-Detection – Economic Considerations |
24. |
Bio-Detection – Personnel Considerations |
25. |
Appendix A: The Threat of Bio-Terror |
25.1. |
Biological Terror |
25.2. |
Bio-Weapons – Historical Perspective |
25.3. |
Biological Terror – Bacterial Agents |
25.3.1. |
Anthrax |
25.3.2. |
Cholera |
25.3.3. |
Plague |
25.3.4. |
Tularemia |
25.4. |
Biological Terror – Viral Agents |
25.4.1. |
Smallpox |
25.4.2. |
Hemorrhagic Fever Viruses |
25.4.3. |
Venezuelan Equine Encephalitis |
25.5. |
Biological Terror – Rickettsiae Agents |
25.5.1. |
Q Fever |
25.5.2. |
Typhus |
25.6. |
Biological Terror – Toxins |
25.6.1. |
Botulinum Toxin |
25.6.2. |
Ricin |
25.6.3. |
Saxitoxin |
25.6.4. |
Staphylococcal Enterotoxin B (SEB) |
26. |
Appendix B: Bio-Detection – Patent Review |
26.1. |
Scope |
26.2. |
Bio-Detection Patents |
27. |
Appendix C: Legal Issues |
27.1. |
International / European Legislation / Agreements |
27.1.1. |
The Biological and Toxin Weapons Convention (BTWC) 1972 |
27.2. |
U.S. Bioterrorism Legislation |
27.3. |
The European Treaties & Legislation |
27.3.1. |
EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks (BICHAT) |